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Hruby and Mac Hadley (University of Arizona, USA) in 1987–1989 Original development program Competitive Technologies → Palatin Technologies , later spun off into PT-141 (bremelanotide) Target: non-selective agonist of MC1R, MC3R, MC4R, MC5R (more potent than α-MSH, longer half-life) Standard experimental dose in human tanning studies: 0.025 mg/kg subcutaneously (Dorr 1996) In Dorr 1996 (n=10): increase in skin melanin density measured by colorimetry by ~25 % after a 10-day course Main adverse effects in the preclinical literature: nausea, flushing, hyperpigmentation (including atypical nevi), priapism Approximately 100+ publications in PubMed
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[DOI] [PubMed] [Google Scholar] 25.Horvath A, Bossis I, Giatzakis C, Levine E, Weinberg F, Meoli E, et al