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FDA highlights concerns with using dietary ingredient glutathione to compound sterile injectables | FDA

The first step in GSH synthesis is the formation of γ-glutamylcysteine (γGC) from the substrates L-glutamate and L-cysteine by glutamylcysteine ligase (GCL) (also referred to as γ-GlutamylCysteine synthetase (γGCS)) [98]

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This could lead to the need to increase doses of some drugs to make them effective or could even result in resistance to the drugs