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Subsequent work has expanded characterisation to mechanistic in vitro models, exploring how amylin and GLP-1 receptor signalling intersect at the hypothalamic level and in the area postrema, regions where both receptor families are co-expressed and regulate appetite circuits

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whereas the plasma GPx activity is mostly due to GPx3, based on the relative expression levels of these GPx enzymes intracellularly and extracellularly and their relative sensitivity to selenium-mediated changes in expression compared with GPx4

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