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SF at the higher dose treatment resulted in both acute and long-term beneficial effects, including upregulation of the phase 2 antioxidant response at the injury site, decreased mRNA levels of inflammatory cytokines in the injured spinal cord, inactivation of urinary macrophage MIF tautomerase activity (which is thought to act by blocking its interaction with the CD74 receptor of macrophages), and by enhancing hindlimb locomotor function, and an increased number of serotonergic axons caudal to the lesion site [248]