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In fact, previous studies have shown that serum LPS has various effects in the CNS, including the overactivation of microglia and an increased production of proinflammatory cytokines (116)

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doi: 10.3389/fphar.2025.1513406 Received 18 October 2024 Accepted 02 January 2025 Published 23 January 2025 Volume 16 - 2025 Edited by Hua Yang, China Pharmaceutical University, China Reviewed by Giovanni Luca Romano, Kore University of Enna, Italy Xinggang Yang, Shenyang Pharmaceutical University, China Updates Copyright © 2025 Yan, Wu, Zhao, Yang, An, Liu and Qi