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Maiti A, DiNardo CD, Rausch CR, Cortes JE, Pemmaraju N, Daver NG, Ravandi F, Garcia-Manero G, Borthakur GM, Naqvi K, Ohanian MN, Short NJ, Alvarado Y, Benton CB, Kadia TM, Takahashi K, Yilmaz ME, MD, Jain N, Kornblau SM, Sasaki K, Andreeff M , Bose P, Ferrajoli A, Issa GC, Jabbour E, Masarova L, Rytting ME, Thompson PA, Wang SA, Konoplev S, Chen Z, Goswami M, Maduike R, Guerrero JA, Zhang Q, Cavazos A, Ma H, Bivins CA, Wade A, Adewale SL, Tse S, Thomas R, Vaughan K, Pierce SA, Ning J, Qiao W, Welch JS, Kantarjian HM, Konopleva MY
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In tumors, cancer cells preferentially use aerobic glycolysis, known as the “Warburg effect”, consuming excessive glucose to generate adenosine triphosphate (ATP) biosynthetic precursors while accumulating lactate ( Accumulating evidence shows that the acidic milieu caused by the build-up of lactate within the TME directly impedes immune cell activation and proliferation, and concomitantly potentiates the functionality of immunosuppressive cells via Kla
