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Morphology of this secondary clone strictly depends on the type of second genetic hit: inactivation of the BAP1 ( BRCA1 -associated protein) gene is the hallmark of BAP1 -inactivated nevus (BIN) ( CTNNB1 or loss of APC is found in deep penetrating nevus (DPN) ( PRKAR1A is typical of pigmented epithelioid melanocytoma (PEM) ( de novo (without a pre-exsisting common nevus): for example, cases of “pure” (non-combined) PEM are also genetically peculiar because often they harbor kinase (most commonly PRKA , but also NTRK1 and NTRK3 ) ( BRAF or NRAS , the three above-mentioned types of melanocytomas are placed within Pathway 1 of melanomagenesis, whose endpoint is superficial spreading melanoma

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Fineman M, Eagle RC Jr, Shields JA, et al

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